Phosphine-mediated [2 + 1] cyclization of coumarins for the efficient construction of cyclopropa[ c ]coumarin scaffolds

Organic & Biomolecular Chemistry 2026

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Authors: Min Xiang, Xing-Xing Dai, Guangwei Wang, Yun-Qing Jia, Li-Wen Shen
DOI: 10.1039/d6ob00204h
Cited by: 1
References: 71

Abstract

A phosphine-mediated [2 + 1] cyclization of coumarins with α-keto esters or isatins enables the construction of cyclopropa[ c ]coumarin scaffolds under mild conditions, exhibits a broad substrate scope, and can be readily scaled to gram quantities.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Cyclopropane Reaction Mechanisms Catalytic Cross-Coupling Reactions

Publication details

Journal / source
Organic & Biomolecular Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
24
Issue
18
Pages
3858–3862
Publication date
1 January 2026
Language
EN