A palladium-catalyzed cascade double annulation reaction to access unsymmetrical di(heteroaryl)methanes

Organic & Biomolecular Chemistry 2026

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Authors: Xing Cai, Huixuan Zhu, Xueli Feng, Hui Deng, Furong Li, Fan Gao, Jiaxin Li, Jingli Zhang
DOI: 10.1039/d6ob00211k
Cited by: 1
References: 60

Abstract

-allylpalladium(II)-catalyzed cycloisomerization of β-chlorovinyl ketones followed by allylic heteroarylation, enabling the rapid construction of diverse heteroaryl units with a flexible methylene linker. Furthermore, initial screening indicated that compound 5fa exhibited potential antitumor activity in HeLa cells with the highest inhibition rate among the selected compounds.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions Synthesis and pharmacology of benzodiazepine derivatives

Publication details

Journal / source
Organic & Biomolecular Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
24
Issue
10
Pages
2111–2117
Publication date
1 January 2026
Language
EN