Synthesis of tri-substituted, aliphatic and 13 C-labelled α,β-unsaturated carboxylic acids via Wittig CO 2 utilisation reactions

Organic & Biomolecular Chemistry 2026 Open access

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Authors: Rachel E Lynch, Amy Lowry, Gerard P. McGlacken, Peter Byrne
DOI: 10.1039/d6ob00221h
Cited by: 1
References: 84

Abstract

Wittig CO 2 utilisation reactions enable rapid construction of α,β-unsaturated carboxylic acids, with regioselective installation of both the carboxyl and alkene groups, and out-compete aldol self-condensation reactions for aliphatic aldehydes.

Fields of Study & Subjects

Phosphorus compounds and reactions Cyclopropane Reaction Mechanisms Synthesis and Reactivity of Sulfur-Containing Compounds

Publication details

Journal / source
Organic & Biomolecular Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
24
Issue
15
Pages
3203–3209
Publication date
1 January 2026
Language
EN