A modular semi-synthetic approach to form a DHA-like polyunsaturated ether lipid with 15-lipoxygenase-1 substrate activity

Organic & Biomolecular Chemistry 2026

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Authors: Mina Bathen, Svanur Sigurjónsson, Karl E. Malterud, Daniel H. Hasselstrøm, Osman Gani, Anders Vik, Haraldur G. Guðmundsson, Guðmundur G. Haraldsson, Trond Vidar Hansen
DOI: 10.1039/d6ob00245e
Cited by: 1
References: 36

Abstract

), comparable to that of arachidonic acid. Finally, a substrate assay with soybean 15-lipoxygenase-1 confirms that the DHA like methoxylated ether lipid is a substrate for the enzyme, displaying 15% relative activity compared to arachidonic acid.

Fields of Study & Subjects

Peroxisome Proliferator-Activated Receptors Fatty Acid Research and Health Lipid metabolism and biosynthesis

Publication details

Journal / source
Organic & Biomolecular Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
24
Issue
17
Pages
3772–3780
Publication date
1 January 2026
Language
EN