Palladium-catalyzed defluorinative coupling of indoles with α,α-difluoro-β,γ-unsaturated ketones: direct access to functionalized α-fluoroenones
Abstract
)-α-fluoroenones in moderate to excellent yields under mild conditions. The reaction exhibits broad substrate scope and functional group tolerance for both coupling partners, including electron-rich, electron-deficient, and sterically hindered indoles, as well as aryl, heteroaryl, and alkyl-substituted fluorinated ketones. It is operationally simple, scalable, and proceeds under ambient atmosphere.
Fields of Study & Subjects
Fluorine in Organic Chemistry
Catalytic C–H Functionalization Methods
Catalytic Cross-Coupling Reactions
Publication details
- Journal / source
- Organic & Biomolecular Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 24
- Issue
- 16
- Pages
- 3442–3448
- Publication date
- 1 January 2026
- Language
- EN