Transaminase-triggered synthesis of 2,5-disubstituted pyrrolidines

Organic & Biomolecular Chemistry 2026 Open access

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Authors: Aoife Martin, Lisa Kennedy, Ishita Solanki, Patricia Fleming, Julia Bruno-Colmenárez, Paul Evans, Marianne Bore Haarr, Elaine O’Reilly
DOI: 10.1039/d6ob00264a
Cited by: 1
References: 30

Abstract

2,5-Disubstituted pyrrolidines were synthesised from ketoenone substrates using a transaminase-triggered intramolecular aza-Michael reaction in moderate to good yields. The dynamic pyrrolidines were stereoselectively resolved by chemical nosylation.

Fields of Study & Subjects

Synthesis and Characterization of Pyrroles Organic and Inorganic Chemical Reactions Synthesis and Biological Activity

Publication details

Journal / source
Organic & Biomolecular Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
24
Issue
12
Pages
2435–2438
Publication date
1 January 2026
Language
EN