One-pot multicomponent synthesis of indole-linked fully substituted fused pyrroles
Abstract
Indoles and pyrroles are valued owing to their natural and pharmaceutical abundance and impressive biological profile. Herein, we report the green and sustainable non-templated synthesis of indole-linked fully substituted fused pyrroles by the multicomponent reactions of arylglyoxals, dimedone, indoles, and anilines. The notable features of the present method include the formation of four new bonds (2 C-C, 2 C-N) under one-pot, catalyst-, and metal-free reaction conditions, and easy isolation of the products by filtration, gram-scale synthesis, and synthesis of pharmaceutically relevant scaffolds.
Fields of Study & Subjects
Synthesis and Characterization of Pyrroles
Multicomponent Synthesis of Heterocycles
Covalent Organic Framework Applications
Publication details
- Journal / source
- Organic & Biomolecular Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 24
- Issue
- 24
- Pages
- 5064–5077
- Publication date
- 1 January 2026
- Language
- EN