Gold( i )-catalyzed regioselective hydroarylation of indole-ynones: an approach to carbazole derivatives

Organic & Biomolecular Chemistry 2026

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Authors: Yu‐Ying Ye, Fang Yang, Wei Hu, Yao Yang, Guo-Jun Pan, Zi‐Sheng Chen, 纪克攻
DOI: 10.1039/d6ob00425c
Cited by: 1
References: 38

Abstract

A gold(I)-catalyzed regioselective umpolung hydroarylation of indole-ynones to dihydrocarbazoles is reported. When a vinyl group is installed at the carbonyl end, ynone umpolung arylation is achieved, followed by tandem Nazarov cyclization to polycycles, while hydroarylation/oxidation directly gives carbazoles. The reaction proceeds under mild conditions with high tolerance for diverse substituents.

Fields of Study & Subjects

Catalytic Alkyne Reactions Sulfur-Based Synthesis Techniques Catalytic C–H Functionalization Methods

Publication details

Journal / source
Organic & Biomolecular Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
24
Issue
18
Pages
3873–3877
Publication date
1 January 2026
Language
EN