Nickel-catalyzed cross-electrophile coupling: applications in natural product synthesis
Abstract
Cross-electrophile coupling (XEC), the reductive cross-coupling of two distinct electrophiles, has emerged as a versatile and powerful strategy for C-C bond formation. The key feature of XEC is its exclusive use of electrophiles, which are generally far more accessible than carbon nucleophiles. Recent advances in nickel-catalyzed cross-electrophile coupling (XEC) using metal reductants or electrosynthesis have significantly advanced the total synthesis of natural products, with this transformation serving as a key step. This review focuses specifically on representative advances in nickel-catalyzed XEC for the efficient construction of complex natural products and bioactive scaffolds in recent years.
Fields of Study & Subjects
Catalytic Cross-Coupling Reactions
Catalytic C–H Functionalization Methods
Sulfur-Based Synthesis Techniques
Publication details
- Journal / source
- Organic & Biomolecular Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 24
- Issue
- 18
- Pages
- 3817–3847
- Publication date
- 1 January 2026
- Language
- EN