Copper-catalyzed xanthine–chalcogenide hybrids: synthesis, DNA binding and docking

Organic & Biomolecular Chemistry 2026

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Authors: Clara Holthausen, Isabella Barbosa dos Reis Carlos, Suzane Quintana, Isis J. A. Granja, Suelen Santos da Silva, A. C. Silva, Eduardo Junca, Matheus V. G. Zimmermann, Ismael Raitz, Leonardo Bruno Federico, Antonio Luiz Braga, Jamal Rafique
+2 more Sumbal Saba, Tiago E. A. Frizon
DOI: 10.1039/d6ob00464d
Cited by: 1
References: 66

Abstract

Copper-catalyzed C–H chalcogenylation of xanthines with diaryl dichalcogenides affords novel hybrids; electron-withdrawing groups enhance reactivity, and selected compounds show strong DNA intercalation with favorable ADME/Tox profiles.

Fields of Study & Subjects

Organoselenium and organotellurium chemistry Sulfur-Based Synthesis Techniques Catalytic C–H Functionalization Methods

Publication details

Journal / source
Organic & Biomolecular Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
24
Issue
28
Pages
5846–5858
Publication date
1 January 2026
Language
EN