Injectable gelatin–PEG hydrogels obtained via cytochrome C-mediated polymerization
Abstract
traditional Fenton systems. The resulting hydrogels, undergoing a sol-gel transition within 1.0 and 2.0 minutes, are biocompatible, and their properties are highly tunable. Indeed, rheological analysis showed that mechanical properties and the linear viscoelastic region (LVR) can be easily modulated by varying the concentrations of the starting methacryl-functionalized gelatin and the crosslinker. Structural characterization and biodegradation studies revealed that enzymatic degradation is strongly dependent on the degree of crosslinking. All hydrogels were readily injectable and showed no detectable cytotoxicity in conditioned-medium assays. Sustained release of rhodamine 101, as a drug-mimicking system, reached ∼70% over 7 days.
Fields of Study & Subjects
Hydrogels: synthesis
properties
applications
Tissue Engineering and Regenerative Medicine
Supramolecular Self-Assembly in Materials
Publication details
- Journal / source
- Organic & Biomolecular Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 24
- Issue
- 30
- Pages
- 6185–6191
- Publication date
- 1 January 2026
- Language
- EN