Synthesis and evaluation of 4-(α-arylvinyl)pyridines as activated linker groups for application in antibody–drug conjugates

Organic & Biomolecular Chemistry 2026 Open access

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Authors: Jack Andrew, Jody Sharpe, Matthew Wallace, Jenny Thirlway, Patrick L. Kerigan Higgs, G. R. Stephenson, Thomas E. Storr, Chris Richards
DOI: 10.1039/d6ob00614k
Cited by: 1
References: 23

Abstract

The rate of thia-Michael addition of glutathione to 2,6-disubstituted-4-vinylpyridines increased by approximately an order of magnitude by introduction of an α-(4-nitrophenyl) substituent.

Fields of Study & Subjects

Catalytic Cross-Coupling Reactions Synthesis and Reactivity of Heterocycles Click Chemistry and Applications

Publication details

Journal / source
Organic & Biomolecular Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
24
Issue
27
Pages
5679–5684
Publication date
1 January 2026
Language
EN