One-pot synthesis of N -arylated benzotriazoles and benzotriazinones via in situ diazotization and aryne trapping
Abstract
from 2-(trimethylsilyl)aryltriflates in the presence of CsF. The methodology exhibits broad functional-group tolerance and was successfully applied to 47 substrates, affording yields in the range of 60-85%. Furthermore, gram-scale synthesis highlights the operational simplicity and practical utility of this approach.
Fields of Study & Subjects
Cyclization and Aryne Chemistry
Chemical Reactions and Mechanisms
Synthesis and pharmacology of benzodiazepine derivatives
Publication details
- Journal / source
- Organic & Biomolecular Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 24
- Issue
- 22
- Pages
- 4696–4711
- Publication date
- 1 January 2026
- Language
- EN