Copper-catalyzed trifluoromethylation of vinyl azides with BrCF 2 CO 2 K: synthesis of α-trifluoromethyl ketones without external fluoride sources

Organic & Biomolecular Chemistry 2026

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Authors: Qinhong Wen, Tianhao Zhang, Xinyu Jia, Yu Wang, Yue Zhao, Taichen Liu, Kai Wei, Zhenghui Kang, Jiuling Li
DOI: 10.1039/d6ob00710d
Cited by: 1
References: 58

Abstract

incorporation through a copper-difluorocarbene pathway. This mild protocol shows broad substrate scope and good functional-group tolerance, establishing a practical method without an additional fluorine source to α-trifluoromethyl ketones. Product derivatizations and mechanistic observations further demonstrate its synthetic utility and support the involvement of a copper-difluorocarbene intermediate, thereby expanding the synthetic potential of metal difluorocarbene chemistry.

Fields of Study & Subjects

Fluorine in Organic Chemistry Inorganic Fluorides and Related Compounds Click Chemistry and Applications

Publication details

Journal / source
Organic & Biomolecular Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
24
Issue
24
Pages
5007–5012
Publication date
1 January 2026
Language
EN