Synthesis of masked α,β-unsaturated trifluoromethyl ketones via iodine( iii )-mediated double decarboxylative trifluoroacetylation

Organic & Biomolecular Chemistry 2026

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Authors: Nan Xia, Ming-Chao Li, Jie Zhou, Jun Xu, Hua‐Jian Xu
DOI: 10.1039/d6ob00763e
Cited by: 1
References: 46

Abstract

a radical pathway, delivering a diverse array of masked α,β-unsaturated trifluoromethyl ketones under simple thermal conditions with broad functional group tolerance. Gram-scale synthesis and downstream transformations highlight the synthetic utility, while mechanistic studies implicate sequential single-electron transfer and decarboxylation events.

Fields of Study & Subjects

Fluorine in Organic Chemistry Vanadium and Halogenation Chemistry Synthesis and Characterization of Pyrroles

Publication details

Journal / source
Organic & Biomolecular Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
24
Issue
23
Pages
4830–4834
Publication date
1 January 2026
Language
EN