Rhodium/copper dual catalysis for defluorinative annulation of gem -difluorocyclopropanes with phenols

Organic & Biomolecular Chemistry 2026

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Authors: Bin Xie, Diandian Xu, Dongfang Jiang, Huawen Huang, Guo‐Jun Deng
DOI: 10.1039/d6ob00949b
Cited by: 1
References: 35

Abstract

-difluorocyclopropanes with phenols. This protocol provides a concise and practical method to construct 2-methylbenzofuran derivatives through consecutive C-F bond cleavage and C-O bond formation, with generally moderate to good yields and high chemo- and regio-selectivity. Mechanistically, our unique rhodium/copper dual catalysis leads to a distinctive defluorinative cyclization pathway to enable benzofuran formation.

Fields of Study & Subjects

Fluorine in Organic Chemistry Cyclopropane Reaction Mechanisms Catalytic C–H Functionalization Methods

Publication details

Journal / source
Organic & Biomolecular Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
24
Issue
31
Pages
6385–6389
Publication date
1 January 2026
Language
EN