Flavoplatins: photoactivated platinum( iv ) prodrugs bearing axial N-donors that trigger pyroptosis and reduce drug resistance
Abstract
Novel photoactivable Pt( iv ) prodrugs have been developed by N -coordination of flavonol-derivatives at the axial position. Upon green-light irradiation, flavoplatins accumulate in the ER and activate the NLRP3/caspase-1/GSDMD pyroptotic pathway.
Fields of Study & Subjects
Photodynamic Therapy Research Studies
Metal complexes synthesis and properties
Nanoplatforms for cancer theranostics
Publication details
- Journal / source
- Inorganic Chemistry Frontiers
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 13
- Issue
- 7
- Pages
- 2835–2842
- Publication date
- 1 January 2026
- Language
- EN