Multifunctional SAHA-derived 8-hydroxyquinoline metallopharmacophores: HDAC inhibition and antiproliferative activity

Inorganic Chemistry Frontiers 2026

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Authors: Chen Chen, Havlínová Barbora, Miroslava Vošahlíková, Ruzena Tuckova, Julia Stjärnhage, Zexiong Lin, Charlotte FJ Rayner, Cyril Barinka, Tilo Söhnel, Stephen Jamieson, Christian G. Hartinger
DOI: 10.1039/d6qi00422a
Cited by: 1
References: 79

Abstract

Conjugation of SAHA (vorinostat), a clinically used pan-HDAC inhibitor, to organometallic scaffolds based on 8-hydoxyquinoline gave potent anticancer agents. The nature of the ligand determined the HDAC inhibitory activity of the compounds.

Fields of Study & Subjects

Histone Deacetylase Inhibitors Research Peptidase Inhibition and Analysis Chemical Synthesis and Analysis

Publication details

Journal / source
Inorganic Chemistry Frontiers
Publisher
Royal Society of Chemistry (RSC)
Volume
13
Issue
14
Pages
6059–6068
Publication date
1 January 2026
Language
EN