Synthesis of chiral α-trifluoromethyl amines via asymmetric reactions of trifluoromethylated imines

Organic Chemistry Frontiers 2026

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Authors: Wei Chen, Wei Chen, Qin Yang, Yiyuan Peng
DOI: 10.1039/d6qo00001k
Cited by: 0
References: 78

Abstract

A review of recent research progress in the synthesis of α-trifluoromethyl amines through the asymmetric reduction of trifluoromethylated imines and nucleophilic addition to trifluoromethylated imines.

Fields of Study & Subjects

Fluorine in Organic Chemistry Asymmetric Synthesis and Catalysis Asymmetric Hydrogenation and Catalysis

Publication details

Journal / source
Organic Chemistry Frontiers
Volume
13
Issue
7
Pages
2159–2177
Publication date
1 January 2026
Language
EN