Tunable CTPhos and chloride enabled direct asymmetric reductive amination for the synthesis of chiral hydroxylamines

Organic Chemistry Frontiers 2026

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Authors: Qishan Liu, Wenji Wang, Biying Liu, Haizhou Huang, Mingxin Chang
DOI: 10.1039/d6qo00012f
Cited by: 0
References: 39

Abstract

The highly modulated and adjustable CTPhos ligands and the chloride anion show excellent enantioselectivity in the first example of direct asymmetric reductive amination of ketones and both N–H and N -alkyl hydroxylamines.

Fields of Study & Subjects

Asymmetric Hydrogenation and Catalysis Asymmetric Synthesis and Catalysis Advanced Synthetic Organic Chemistry

Publication details

Journal / source
Organic Chemistry Frontiers
Volume
13
Issue
8
Pages
2394–2400
Publication date
1 January 2026
Language
EN