Pyridine-boryl radical mediated synthesis of quinolines via α-amino radical formation and intramolecular alkenyl sulfone trapping

Organic Chemistry Frontiers 2026 Open access

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Authors: Raúl Valderrama-Callejón, Inés Alberdi Alonso, Sara Gómez, David Jiménez, Gonzalo Dorado-Briones, Emily L. Vargas, Mariola Tortosa, M. B. Cid
DOI: 10.1039/d6qo00132g
Cited by: 1
References: 58

Abstract

process. According to our experiments and DFT calculations, the sulfonyl moiety plays a crucial role in the cyclization and aromatization processes, which occur in two steps: elimination of the sulfonyl radical and hydrogen atom abstraction, facilitating both aromatization and regeneration of the pyridine-boryl radical. The approach represents a useful application of radical-based methodologies for heterocycle synthesis under mild and catalytic conditions.

Fields of Study & Subjects

Radical Photochemical Reactions Organoboron and organosilicon chemistry Catalytic C–H Functionalization Methods

Publication details

Journal / source
Organic Chemistry Frontiers
Publisher
Royal Society of Chemistry (RSC)
Volume
13
Issue
10
Pages
3208–3214
Publication date
1 January 2026
Language
EN