Enantioselective cycloaddition desymmetrization en route to multi-stereogenic atropisomers

Organic Chemistry Frontiers 2026

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Authors: Tian-Yi Hu, Hao-Jie Meng, Bin Ma, Ting Deng, Jie Chen, Ling Zhou
DOI: 10.1039/d6qo00202a
Cited by: 3
References: 70

Abstract

Chiral phosphoric acid-catalyzed cycloaddition desymmetrization of dialdehydes simultaneously constructs axial and central chirality, providing biaryl and biaryl ether atropisomers in high yields with excellent stereoselectivity.

Fields of Study & Subjects

Axial and Atropisomeric Chirality Synthesis Asymmetric Synthesis and Catalysis Synthesis and Properties of Aromatic Compounds

Publication details

Journal / source
Organic Chemistry Frontiers
Publisher
Royal Society of Chemistry (RSC)
Volume
13
Issue
11
Pages
3294–3303
Publication date
1 January 2026
Language
EN