Defining substrate specificities of N -acetylglucosamine-6- O -sulfotransferases for enzymatic modular assembly of sulfated O -glycans

Organic Chemistry Frontiers 2026 Open access

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Authors: Shuquan Fan, Jinghua Han, Tangliang Shen, Mohammadhossein Shabahang, Zhenming Du, Jun pan, Guitao Bai, Shumin Bao, Avinash Ittuveetil, Lei Li
DOI: 10.1039/d6qo00226a
Cited by: 1
References: 63

Abstract

The substrate specificity of CHST2 and CHST6 demonstrated a strong preference for sulfating β1-6 linked terminal GlcNAc residues on O -glycans, enabling the enzymatic modular construction of diverse sulfated O -glycan structures.

Fields of Study & Subjects

Glycosylation and Glycoproteins Research Carbohydrate Chemistry and Synthesis Proteoglycans and glycosaminoglycans research

Publication details

Journal / source
Organic Chemistry Frontiers
Publisher
Royal Society of Chemistry (RSC)
Volume
13
Issue
11
Pages
3414–3424
Publication date
1 January 2026
Language
EN