Design of 365 nm light-triggered fluorogenic crosslinking via a genetically encoded 3-CF 3 - p -phenylenediamine-lysine featuring red-shifted photo-defluorination

Organic Chemistry Frontiers 2026

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Authors: Fan Zhang, Ziming Xiong, Siyu Kuang, Sitong Li, Xiaohu Zhao, Zhipeng Yu
DOI: 10.1039/d6qo00284f
Cited by: 1
References: 33

Abstract

3-CF3-PDAK, a 2 nd -gen GCE-encoded photo-crosslinking ncAA, outperforms m -TFMAK via 365 nm light, showing a longer AcF half-life and fluorogenicity. When encoded in E. coli /mammalian cells, it enables visualization of PPIs via a photo-DAFEx reaction.

Fields of Study & Subjects

Photochromic and Fluorescence Chemistry Fluorine in Organic Chemistry Light effects on plants

Publication details

Journal / source
Organic Chemistry Frontiers
Publisher
Royal Society of Chemistry (RSC)
Volume
13
Issue
12
Pages
3646–3652
Publication date
1 January 2026
Language
EN