Pd-catalyzed site-selective dehydrogenative alkenyl etherification of tyrosine residues in peptides and proteins

Organic Chemistry Frontiers 2026

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Authors: Xia Liu, Wei Zeng, Jianjun Zhang, Peng Wang, Neeli Satyanarayana, Qing Zhu
DOI: 10.1039/d6qo00358c
Cited by: 1
References: 29

Abstract

A palladium-catalyzed method for the site-selective O -alkenylation of tyrosine residues is reported, enabling efficient and chemoselective bioconjugation under mild conditions.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions Chemical Synthesis and Analysis

Publication details

Journal / source
Organic Chemistry Frontiers
Publisher
Royal Society of Chemistry (RSC)
Volume
13
Issue
13
Pages
3900–3908
Publication date
1 January 2026
Language
EN