Lysine-tolerant N-terminal amidination of unprotected peptides

Organic Chemistry Frontiers 2026

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Authors: Wang Gu, Xiao-Yu Luo, Rui Feng, Fa‐Jie Chen, Wanzhen Lin, Fener Chen
DOI: 10.1039/d6qo00667a
Cited by: 1
References: 31

Abstract

Late-stage modification at the N-terminal α-amine of unprotected peptides is a valuable tool for peptide diversifications, yet it is challenging due to the competition from lysine ε-amines.

Fields of Study & Subjects

Chemical Synthesis and Analysis Peptidase Inhibition and Analysis Advanced Proteomics Techniques and Applications

Publication details

Journal / source
Organic Chemistry Frontiers
Publisher
Royal Society of Chemistry (RSC)
Volume
13
Issue
17
Pages
5632–5640
Publication date
1 January 2026
Language
EN