Brønsted acid-facilitated practical reduction of tertiary amides to amines via iridium-catalyzed hydrosilylation with low catalyst loading

Organic Chemistry Frontiers 2026 Open access

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Authors: Yu‐Qing Li, Xin Xu, Yun-Feng Zhou, Pei‐Qiang Huang
DOI: 10.1039/d6qo00797j
Cited by: 1
References: 126

Abstract

We report a practical and chemoselective method for the direct reduction of tertiary amides to amines under mild conditions using Vaska's Ir-complex with low catalyst loading and inexpensive Brønsted acids.

Fields of Study & Subjects

Organoboron and organosilicon chemistry Chemical Synthesis and Analysis Advanced Synthetic Organic Chemistry

Publication details

Journal / source
Organic Chemistry Frontiers
Publisher
Royal Society of Chemistry (RSC)
Volume
13
Issue
17
Pages
5819–5832
Publication date
1 January 2026
Language
EN