Pyrazolo[3,4- d ]pyrimidine derivatives as VEGFR-2 and EGFR T790M dual inhibitors: design, docking, ADMET, synthesis and anticancer evaluations

RSC Advances 2026 Open access

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Authors: Nada A. A. M. Aziz, Riham F. George, Tamer M. Nasr, Khaled El‐Adl, Ghada F. Elmasry

DOI: 10.1039/d6ra00037a

Cited by: 5

References: 63

Abstract

inhibition. Furthermore, molecules 7c, 7e and 8b exhibited excellent ADMET profile compared to sorafenib and erlotinib.

HER2/EGFR in Cancer Research Lung Cancer Treatments and Mutations Colorectal Cancer Treatments and Studies

References 63