Glutathione-responsive deformable manganese-based nanomedicines for enhanced tumor-specific chemotherapy

RSC Advances 2026 Open access

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Authors: Pengcheng Li, Jun Tao, Xinzeyu Yi, Qinghui Qi, Zhou Liang, Ye Wu, Wubulitalipu Xirena, Chenxian Ye, Yunqin Ke, Lianhui Wang, Wanrong Yi
DOI: 10.1039/d6ra00177g
Cited by: 0
References: 20

Abstract

experiments reveal that their enhanced cellular uptake, multicellular spheroid penetration, and tumor accumulation, increased by 17.64-fold, 2.25-fold and 1.6-fold, compared to that of the stiff counterpart, respectively. Additionally, an excellent specific chemotherapy efficacy with tumor growth inhibition was realized in a mice OS model, by intravenous administration of DMNs. In conclusion, glutathione-responsive deformable manganese-based nanomedicines demonstrate clinical potential by addressing the limitations of precision manganese and dopamine delivery and achieving enhanced tumor-specific chemotherapy for osteosarcoma.

Fields of Study & Subjects

Nanoplatforms for cancer theranostics Nanoparticle-Based Drug Delivery Radiation Therapy and Dosimetry

Publication details

Journal / source
RSC Advances
Volume
16
Issue
9
Pages
8255–8263
Publication date
1 January 2026
Language
EN