Molecular and physicochemical arrangement of chitosan–ibuprofen matrices for topical drug delivery on skin: preparation impact

RSC Advances 2026 Open access

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Authors: Barbara Gieroba, Vladyslav Vivcharenko, Grzegorz Kalisz, Paulina Kazimierczak, Olena Mozgova, Maryna Khalavka, L.V. Nosach, Izabela S. Pieta, Robert Nowakowski, Agata Przekora, Anna Sroka-Bartnicka
DOI: 10.1039/d6ra00296j
Cited by: 2
References: 91

Abstract

region indicating interactions between IBU and CS functional groups. Among the investigated systems, 2% (w/v) medium-molecular-weight chitosan demonstrated the most favorable sustained IBU release (∼50% after 48 h), highlighting its potential for dermal drug delivery and personalized therapeutic applications.

Fields of Study & Subjects

Advancements in Transdermal Drug Delivery Advanced Drug Delivery Systems Wound Healing and Treatments

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
17
Pages
15591–15608
Publication date
1 January 2026
Language
EN