Design, synthesis and anticonvulsant evaluation of novel 2,4,5-trichlorobenzenesulfonate-based dihydrothiazoles supported by in vivo and in silico studies

RSC Advances 2026 Open access

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Authors: Faiqa Noreen, Muhammad Iftikhar Shoukat, Imran Imran, Farhan Siddique, Sumaira Nadeem, Mostafa A. Ismail, Xianliang Zhao, Magdi E. A. Zaki, Sobhi M. Gomha, Zahid Shafiq
DOI: 10.1039/d6ra00305b
Cited by: 5
References: 44

Abstract

findings, compound 3c emerged as the most important candidate, demonstrating superior anti convulsant activity across multiple seizure models. These results underscore the capability of the newly synthesized 2, 4, 5-trichlorobenzenesulfonate based dihydrothiazoles as promising scaffolds for the development of new antiepileptic drugs.

Fields of Study & Subjects

Synthesis and biological activity Synthesis of Tetrazole Derivatives Enzyme function and inhibition

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
13
Pages
12100–12118
Publication date
1 January 2026
Language
EN