2-Pyridone-assisted palladium-catalyzed regioselective arylation of naphthamides
Abstract
The 2-pyridone scaffold receives attention in medicinal chemistry due to its bioisostere properties, which significantly contributing to lipophilicity, solubility, metabolic stability, and drug off-target effects. In the present article, we report the 2-pyridone-assisted regioselective arylation of naphthamides. Using diversified naphthamides and aryl iodides, a wide variety of 2-pyridone-containing molecular scaffolds were synthesized in good yields, which could be potentially useful in medicinal chemistry.
Fields of Study & Subjects
Catalytic Cross-Coupling Reactions
Catalytic C–H Functionalization Methods
Sulfur-Based Synthesis Techniques
Publication details
- Journal / source
- RSC Advances
- Volume
- 16
- Issue
- 14
- Pages
- 12180–12185
- Publication date
- 1 January 2026
- Language
- EN