Scaffold-based biomaterials in ovarian tissue engineering

RSC Advances 2026 Open access

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Authors: Chiara Di Berardino, Liliana Liverani, Aldo R. Boccaccini, Camila Cecilia Rojo-Fleming, Gianna Sacchetti, Alessia Peserico, Chiara Camerano Spelta Rapini, Giulia Capacchietti, Barbara Barboni
DOI: 10.1039/d6ra00380j
Cited by: 4
References: 120

Abstract

applications of gel-like hydrogels, decellularized extracellular matrix-derived scaffolds, electrospun fibrous constructs and 3D-printed architectures. Natural and ECM-based materials provide tissue-specific biological cues but are limited by variability and mechanical instability, whereas synthetic scaffolds, particularly electrospun poly(ε-caprolactone), offer superior control over architecture, reproducibility and scalability, supporting follicle survival across multiple mammalian models. Overall, hybrid biomaterial strategies integrating biological activity with engineered scaffold tunability emerge as the most promising platforms for artificial ovary development, while standardization and translational validation remain key challenges.

Fields of Study & Subjects

Reproductive Biology and Fertility 3D Printing in Biomedical Research Advanced Materials and Mechanics

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
13
Pages
11530–11542
Publication date
1 January 2026
Language
EN