Development of new pyrazole–thiophene hybrids: synthesis, anticancer assessment, and molecular docking insights

RSC Advances 2026 Open access

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Authors: Sonia Samy, Samar E. Mahmoud, Ebrahim Abdel‐Galil, Ehab Abdel-Latif, Gehad E. Said
DOI: 10.1039/d6ra00429f
Cited by: 6
References: 49

Abstract

assessment of the pharmacokinetic profile using the SwissADME program showed that compounds 9a and 9b appeared as the most promising nominees within the series, demonstrating proper solubility, lower lipophilicity, and, for compound 9a, high GI absorption. This study presents noteworthy ADME challenges for the series, particularly regarding their solubility and permeability, leading to the need for more synthetic efforts towards more metabolically stable and bioavailable analogues. These findings suggest that pyrazole-thiophene hybrids represent promising scaffolds for the further development of potent anticancer agents.

Fields of Study & Subjects

Synthesis and biological activity Cancer therapeutics and mechanisms Enzyme function and inhibition

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
12
Pages
10665–10678
Publication date
1 January 2026
Language
EN