Thiadiazole–azetidinone sulfonamide hybrids with antimycobacterial activity supported by structure-based analysis

RSC Advances 2026 Open access

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Authors: Subham Kumar Vishwakarma, Achal Mishra, Naresh Kumar Panigrahi, Cesar Augusto Roque-Borda
DOI: 10.1039/d6ra00735j
Cited by: 3
References: 34

Abstract

ADMET analysis indicated acceptable drug-like profiles across the scaffold. Rather than defining a clinically optimized candidate, this work establishes a structure-activity and structure-interaction framework that supports the thiadiazole-azetidinone hybrid concept and guides future chemical optimization toward antitubercular agents.

Fields of Study & Subjects

Synthesis of β-Lactam Compounds Quinazolinone synthesis and applications Synthesis and biological activity

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
17
Pages
15553–15568
Publication date
1 January 2026
Language
EN