Synthesis of sulfanyl derivatives of 1,2,4-triazoles via an acid catalyzed intramolecular cyclization of isothiosemicarbazones: structural characterization, E / Z isomerism, mechanistic insights and in vitro cytotoxicity

RSC Advances 2026 Open access

Read full text
Authors: Kallivalappil Snisha, Mano Chitra Karthikeyan, Nattamai S. P. Bhuvanesh, Antony Joseph Velanganni Arockiam, Ramasamy Karvembu
DOI: 10.1039/d6ra00822d
Cited by: 0
References: 60

Abstract

Sulfanyl derivatives of 1,2,4-triazoles were synthesized via a Lewis or Brønsted acid catalyzed intramolecular cyclization of isothiosemicarbazones, and their cytotoxicity was evaluated.

Fields of Study & Subjects

Structural and Chemical Analysis of Organic and Inorganic Compounds Synthesis and Characterization of Heterocyclic Compounds Heterocyclic Compound Synthesis and Bioactivity

Publication details

Journal / source
RSC Advances
Volume
16
Issue
15
Pages
13433–13446
Publication date
1 January 2026
Language
EN