Multitarget synthetic piperates against key drug targets of Alzheimer's and diabetes mellitus

RSC Advances 2026 Open access

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Authors: Asif Ahmad, Uzma Salar, Musa Özil, Nimet Baltaş, Maria Nasim, Aaqib Ullah, Z. Ul-Haq, Khalid Mohammed Khan, Farzana SHAHEEN
DOI: 10.1039/d6ra00843g
Cited by: 1
References: 42

Abstract

studies identified key interactions between inhibitors and the active-site residues of each target. All compounds also displayed reasonable antioxidant potential, as evidenced by FRAP, CUPRAC, and DPPH assays, compared with the standard butylated hydroxytoluene (BHT). Detailed pharmacokinetic and ADME profiles were also predicted to assess the druggability of the compounds. The identified ligands have multitarget potential to inhibit the key enzymes associated with diabetes and Alzheimer's. They may serve as lead candidates for later stages of drug development.

Fields of Study & Subjects

Piperaceae Chemical and Biological Studies Pharmacological Receptor Mechanisms and Effects Ion Channels and Receptors

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
19
Pages
17085–17113
Publication date
1 January 2026
Language
EN