New isoxazole-based heterocyclic hybrids with dual antimicrobial and antioxidant bioactivity: integrated synthesis, in vitro assessment, and computational exploration

RSC Advances 2026 Open access

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Authors: Aziz Arzine, Soumia Ait Assou, Lamiae El Bouamri, Mohammed Chalkha, Asmae Nakkabi, Samir Chtita, Reem M. Aljowaie, Mourad A. M. Aboul-Soud, Mohammed El Hassouni, John P. Giesy, Mohamed El Yazidi
DOI: 10.1039/d6ra01005a
Cited by: 3
References: 75

Abstract

predictions of Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADME-Tox) analysis predicted 5d to possess an optimal profile, with high gastrointestinal absorption and minimal toxicity, highlighting it as the lead candidate for the development of broad-spectrum antimicrobial drugs.

Fields of Study & Subjects

Synthesis and biological activity Multicomponent Synthesis of Heterocycles Synthesis of heterocyclic compounds

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
15
Pages
13515–13528
Publication date
1 January 2026
Language
EN