Electrospun nanofiber membrane of chitosan/polyvinyl alcohol embedded with DOX-loaded V-MOFs for controlled drug release and multifunctional biological activity

RSC Advances 2026 Open access

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Authors: Ahlem Guesmi, Naoufel Ben Hamadi, Wesam Abd El-Fattah, Mohamed G. El-Desouky, Ashraf A. El-Bindary
DOI: 10.1039/d6ra01018k
Cited by: 21
References: 79

Abstract

. Optimization through a Box-Behnken design revealed that pH, temperature, and time are significant parameters controlling the dynamics of drug release. These results support the hypothesis that DOX@V-MOF nanofibers may serve as a new mechanism for controlled drug release in localized cancer therapy along with multiple biomedical applications requiring integrated anticancer, antioxidant, and antimicrobial properties.

Fields of Study & Subjects

Metal-Organic Frameworks: Synthesis and Applications Covalent Organic Framework Applications Electrospun Nanofibers in Biomedical Applications

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
20
Pages
17650–17675
Publication date
1 January 2026
Language
EN