Synthesis, cholinesterase/MAO-A inhibition, antioxidant potential and detailed computational analysis of 3,5-difluorobenzenesulfonate-tagged ethoxyvanillin hydrazones

RSC Advances 2026 Open access

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Authors: Arooj Fatima, Faiqa Noreen, Halil Şenol, Parham Taslimi, Mostafa A. Ismail, Rima D. Alharthy, Asif Rasool, Magdi E. A. Zaki, Sobhi M. Gomha, Zahid Shafiq
DOI: 10.1039/d6ra01071g
Cited by: 1
References: 63

Abstract

values ranging from 35.94 to 64.27 µM, indicating a favorable safety profile within the tested concentration range. The outcomes highlighted the substantial multifunctional potential of the evaluated hydrazones as AChE, BChE, and MAO-A inhibitors with complementary antioxidant activity, and cytotoxicity results indicated their potential for further advancement in the management of neurodegenerative conditions.

Fields of Study & Subjects

Cholinesterase and Neurodegenerative Diseases Enzyme function and inhibition Free Radicals and Antioxidants

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
26
Pages
23987–24005
Publication date
1 January 2026
Language
EN