Green-synthesized Matricaria chamomilla silver nanoparticles enhance anticonvulsant and neuroprotective effects through GABAergic and antioxidant pathways in an acute seizure rat model

RSC Advances 2026 Open access

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Authors: Yahya Alhamhoom, Rupesh KUMAR M, Manjunath C, K.J. Kavitha, Mohamed Rahamathulla, Hanan Albataineh, Syeda Ayesha Farhana, Mohammed Muqtader Ahmed, Thippeswamy Boreddy Shivanandappa, Ismail Pasha
DOI: 10.1039/d6ra01236a
Cited by: 1
References: 59

Abstract

tissue) and oxidative stress parameters improved. The histopathological assessments revealed minimal neuronal damage. Overall, MC-AgNPs demonstrated superior efficacy compared to the crude extract, indicating that nano-formulation could enhance the therapeutic potential of plant-derived agents in epilepsy management, suggesting a cost-effective adjunct therapy deserving further research studies.

Fields of Study & Subjects

Medicinal Plants and Neuroprotection Nanoparticles: synthesis and applications Saffron Plant Research Studies

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
25
Pages
23078–23094
Publication date
1 January 2026
Language
EN