Design, synthesis, and antiproliferative activity of novel thiazole-based derivatives as tubulin polymerization inhibitors targeting the colchicine binding site

RSC Advances 2026 Open access

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Authors: Lamya Hamad Al-Wahaibi, Ali M. Elshamsy, Taha F.S. Ali, Bahaa G. M. Youssif, Stefan Bräse, Mohamed Abdel‐Aziz, Nawal A. El‐Koussi
DOI: 10.1039/d6ra01355d
Cited by: 1
References: 45

Abstract

ADMET predictions further supported 9k as a drug-like lead with acceptable oral exposure and a beneficial P-gp-related transporter profile. The enhanced apoptotic effects of 9k compared with Staurosporine make 9k an attractive lead candidate for further development as an anti-cancer drug targeting the colchicine-binding site.

Fields of Study & Subjects

Synthesis and biological activity Synthesis and Characterization of Pyrroles Curcumin's Biomedical Applications

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
27
Pages
25103–25115
Publication date
1 January 2026
Language
EN