Towards hybrid MOF@COF and COF@MOF platforms for next-generation biocatalysis

RSC Advances 2026 Open access

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Authors: Mercy Chaparadza, Linia Gedi Marazani, Lendly Moyo, Evernice Chikukwa, Piwai Tshuma, Johannes Hungwe, Gift Mehlana
DOI: 10.1039/d6ra01830k
Cited by: 1
References: 77

Abstract

encapsulation, covalent binding, and adsorption-based immobilization, emphasizing how hybrid frameworks enhance enzyme protection, substrate diffusion, and cascade catalysis. Key challenges including scalability, enzyme leaching, and synthesis reproducibility are also critically examined. Finally, we outline future opportunities for rational design of hybrid frameworks that enable precise enzyme spatial organization and multi-enzyme systems, paving the way for next-generation, sustainable biocatalytic technologies.

Fields of Study & Subjects

Metal-Organic Frameworks: Synthesis and Applications Covalent Organic Framework Applications Advanced Nanomaterials in Catalysis

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
26
Pages
23613–23624
Publication date
1 January 2026
Language
EN