A QbD optimization of a pH-responsive Eudragit S100–chitosan nanoformulation for the co-delivery of pentoxifylline and simvastatin in colorectal cancer therapy

RSC Advances 2026 Open access

Read full text
Authors: Samar M. Mahgoub, Seham M. Hamed, Ahmed A Allam, Doaa R. I. Abdel-Gawad, Ahmed G. Soliman, Khaled Metwally, Rehab Mahmoud
DOI: 10.1039/d6ra02003h
Cited by: 1
References: 58

Abstract

) compared to free drugs through caspase-3 activation and suppression of proliferative (Ki-67) and angiogenic vascular endothelial growth factor (VEGF) markers confirming its apoptotic effects. By integrating the established Eudragit S100-chitosan carrier with the novel co-delivery of pentoxifylline and simvastatin, coupled with QbD optimization and comprehensive therapeutic evaluation, this work presents a distinct and innovative multi-targeted therapeutic strategy for CRC with improved efficacy and reduced off-target effects.

Fields of Study & Subjects

Nanoparticle-Based Drug Delivery Advanced Drug Delivery Systems Advancements in Transdermal Drug Delivery

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
30
Pages
27847–27877
Publication date
1 January 2026
Language
EN