Benzimidazole derivatives as dual EGFR and BRAF V600E inhibitors with pro-apoptotic antiproliferative potential

RSC Advances 2026 Open access

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Authors: Lamya Hamad Al-Wahaibi, Mohamed Samir, Stefan Bräse, Bahaa G. M. Youssif, Martha M. Morcoss
DOI: 10.1039/d6ra02117d
Cited by: 1
References: 40

Abstract

ADME profiling and drug-likeness analysis revealed that compound 8d exhibits high gastrointestinal absorption and adheres to Lipinski's rule of five, supporting its potential as an oral therapy.

Fields of Study & Subjects

Melanoma and MAPK Pathways Protein Kinase Regulation and GTPase Signaling NF-κB Signaling Pathways

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
28
Pages
25216–25228
Publication date
1 January 2026
Language
EN