Aqueous bio-based hydrotropic solutions for green extraction of glycyrrhizic acid from licorice: experimental investigation and mechanistic insights

RSC Advances 2026 Open access

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Authors: Nhan Trong Le, Hang Thanh Thi Phan, The‐Huan Tran, Hung The Nguyen, Hoai Thi Nguyen
DOI: 10.1039/d6ra02244h
Cited by: 1
References: 43

Abstract

). An integrated macroporous resin-based strategy enabled efficient GA recovery with a recovery efficiency of 92.98% and high GA content (80.31%), while maintaining stable extraction performance and solvent recovery above 95.50% over three reuse cycles. Furthermore, GA-enriched fraction obtained using ABHS exhibited enhanced nitric oxide inhibitory activity without detectable cytotoxic effects on normal human cells, as supported by molecular docking analysis. In this context, the present study establishes ABHS as efficient, sustainable, and mechanistically transparent platforms for GA extraction, offering a promising green strategy for amphiphilic triterpenoid saponins.

Fields of Study & Subjects

Pharmacological Effects of Natural Compounds Hormonal Regulation and Hypertension Biochemical and biochemical processes

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
23
Pages
20866–20882
Publication date
1 January 2026
Language
EN