CellTrap: an instrument-free microfluidic platform for cell–cell interactions at stochastically generated effector-to-target ratios

RSC Advances 2026 Open access

Read full text
Authors: Muhammad Zia Ullah Khan, Morteza Hasanzadeh Kafshgari, Ali Bashiri Dezfouli, Oliver Hayden, G Multhoff, Ghulam Destgeer
DOI: 10.1039/d6ra02345b
Cited by: 1
References: 53

Abstract

, K562 leukemia, and LS174T adenocarcinoma targets. Continuous time-lapse imaging seamlessly linked early transient intracellular calcium fluxes (indicating target engagement) to distinct, contact-dependent cytotoxic outcomes. Our data demonstrate that increasing E : T ratios consistently enhances immune-mediated target lysis, highlighting the platform's robust utility for dissecting complex immune-cancer dynamics and guiding the development of personalized immunotherapies.

Fields of Study & Subjects

3D Printing in Biomedical Research Microfluidic and Bio-sensing Technologies Single-cell and spatial transcriptomics

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
21
Pages
19024–19037
Publication date
1 January 2026
Language
EN