DNA origami-engineered gold nanoparticle multimers for ultrasensitive, label-free SERS detection of small molecules and biomolecules

RSC Advances 2026 Open access

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Authors: Yaosen Wang, Yanlong Cai, Huaizhou Jin, Shangzhong Jin
DOI: 10.1039/d6ra02441f
Cited by: 1
References: 45

Abstract

clearly resolved. Furthermore, we demonstrate the versatility of this platform by detecting proteins (streptavidin, thioredoxin) at sub-picomolar levels. Our work establishes DNA-origami-engineered multimers as a robust and generalizable strategy for ultrasensitive, label-free biochemical sensing.

Fields of Study & Subjects

Gold and Silver Nanoparticles Synthesis and Applications Advanced biosensing and bioanalysis techniques Plasmonic and Surface Plasmon Research

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
23
Pages
21266–21276
Publication date
1 January 2026
Language
EN