Design, synthesis, biological evaluation, and molecular dynamics study of asymmetric N -isopropyl-4-piperidone diarylpentanoids as potential anticancer and anti-inflammatory agents

RSC Advances 2026 Open access

Read full text
Authors: Huy-Khoa Tran, Truc-Vy Mai, Van-Dung Le, Tran-Nguyen Minh-An, Dinh‐Tri Mai, Quoc-Tuan Tran, Thi Quyen Vu, Thanh–Danh Nguyen, Chi–Hien Dang
DOI: 10.1039/d6ra02446g
Cited by: 1
References: 47

Abstract

Novel asymmetric N -isopropyl-4-piperidone diarylpentanoids were rationally designed with a push–pull system. Compound KB2d emerges as a potent dual anticancer and anti-inflammatory agent.

Fields of Study & Subjects

Synthesis and biological activity Synthesis of heterocyclic compounds Enzyme function and inhibition

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
25
Pages
22713–22734
Publication date
1 January 2026
Language
EN