Design, synthesis, bioevaluation, and in silico insights of pyrazole-pyrrolinone and pyridazinone hybrids as potential antimicrobial agents

RSC Advances 2026 Open access

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Authors: Sayed K. Ramadan, Selwan Hamed, Hoda A. Ahmed, Tarfah Al-Warhi, Nuha S. Alharbi, Eman A. E. El-Helw
DOI: 10.1039/d6ra02508k
Cited by: 3
References: 38

Abstract

This study focused on design and synthesis of novel pyrazole-pyrrolinone and pyridazinone derivatives and evaluation of their antimicrobial, antibiofilm, and mechanistic properties to identify promising lead compounds.

Fields of Study & Subjects

Synthesis and biological activity Synthesis and Characterization of Pyrroles Synthesis of Tetrazole Derivatives

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
28
Pages
25529–25547
Publication date
1 January 2026
Language
EN